Project Twenty21 - August Update

Get Project Twenty21 Updates via Email Project Twenty21: August Update 16th August 2022 We’re doing some work behind the scenes to revamp the way our monthly T21 data update is laid out, so this month’s data points will be a little delayed and released as soon as they are ready – please bear with us! In the meantime,  …


How to read a paper on the short-term impairing effects of cannabis: A selective and critical review of the literature

Author Michael A White, Nicholas R Burns Published August 15, 2022 Abstract The prosecution of cannabis-presence driving offences (in the absence of any behavioural evidence of impairment) is ultimately based on the assumption that there is a tight causal relationship between positive toxicology for cannabis and impairment. The main purpose of this review is to  …


The Psychedelic Access and Research European Alliance

The Psychedelic Access and Research European Alliance (PAREA) has officially launched with an impressive array of wide-ranging support amongst charities, patient groups, not-for-profits and psychedelic industry partners.  Drug Science was an incubator for the PAREA collective. We recognised that to ensure that psychedelic-assisted psychotherapy was integrated into each EU member state’s healthcare system, a centralised  …


The Drug Enforcement Agency listens to psychedelic experts

By Professor David Nutt and James Bunn The Drug Enforcement Agency (DEA) recently withdrew a proposal to ban five psychedelic substances: 4-Hydroxy-N,N-diisopropyltryptamine (4-OH-DiPT), 5-Methoxy-alphamethyltryptamine (5-MeO-AMT), N-Isopropyl-5-Methoxy-N-Methyltryptamine (5-MeO-MiPT), N,N-Diethyl-5-methoxytryptamine (5-MeO-DET), and N,N-Diisopropyltryptamine (DiPT). Earlier this year, the DEA proposed that these substances ought to be moved to schedule 1 (the most restrictive schedule in the Controlled  …


Legal psilocybin prescriptions in Canada

What is the Special Access Programme? On January 5th 2022, Health Canada amended the Food and Drug Regulations and the Narcotic Control Regulations to allow previously excluded ‘psychedelic’ drugs such as Psilocybin to be included on the ‘Special Access Programme’ (SAP). The SAP allows healthcare practitioners to request limited access to drugs that are not  …


State naloxone co-prescribing laws show mixed effects on overdose mortality rates

Author MaryKate Duska, Jared M. Rhoads, Elizabeth C. Saunders, Tracy Onega Published July 25, 2022 Objective To examine the relative changes in opioid overdose mortality rates between states that have and have not adopted naloxone co-prescribing laws. Methods We performed a synthetic control analysis. National Vital Statistics data for the years 2012–2018 were analysed, and  …


Eating ourselves to death: How food is a drug and what food abuse costs

Author Matthew Robinson Published July 18, 2022 Abstract The objective of this paper is to examine definitions of the terms “drug,” “drug use, “drug abuse,” and “addiction” to determine if the most commonly consumed foods in America are similar or consistent with drug use, abuse, and addiction. The methodology consists of reviewing published studies in  …


Project Twenty21 - July Update

Get Project Twenty21 Updates via Email Our Project Twenty21 monthly updates have changed. From now on, we will be incorporating the medical cannabis news (previously included in our T21 mailout) into the Drug Science newsletter which goes out around the first Tuesday of every month. This means that from next month you will receive a second  …


Diamorphine-Assisted Treatment

Diamorphine-assisted treatment is the prescription and provision of hygienic, medical-grade diamorphine to patients in a clinical set-up – patients attend a clinic and are dosed by a clinician once or twice a day depending on individual needs. Drug-related deaths in the UK have risen significantly over the past 10 years, with a steep increase in  …


The Misuse of Drugs Regulations 2001: A case study in poor legislative drafting

Author Cathal T Gallagher Published July 11, 2022 Abstract The Misuse of Drugs Regulations 2001 (MDRs) create exemptions to the offences of possession, production, supply, and administration of controlled drugs (CDs), which are necessary to allow healthcare professionals to treat patients without rendering themselves liable to prosecution for various offences under the Misuse of Drugs  …


Over One Hundred Years of MDMA Research

Written by Libby Furminger   History 3,4-Methylenedioxymethamphetamine (MDMA), also known as Mandy, Molly, Ecstasy or ‘E’, is a class A drug known for inducing feelings of happiness, chattiness, liveliness, and overall feelings of ecstasy, making it a common adjacent to enhancing raves, clubs and parties. Lesser known, MDMA has historically also been used in research  …


Professor Sir Colin Blakemore and Drug Science

“All of us at Drug Science were saddened to hear earlier this week of the death of Colin following his year-long battle with motor-neuron disease. Colin was instrumental in the founding of our charity in 2010, coming to the first planning meeting and staying with us as member, a trustee and finally a patron for  …


Cannabinoids and the endocannabinoid system in fibromyalgia: a review of preclinical and clinical research

Authors Stephanie Bourke, Anne Schlag, Saoirse Elizabeth O’Sullivan, David Nutt, David Finn Published May 21, 2022 Fibromyalgia affects millions of people worldwide and has a significant impact on quality of life. Fibromyalgia symptoms include persistent widespread pain, fatigue, stiffness, sleep disturbances and cognitive dysfunction. Endogenous cannabinoids (endocannabinoids), the body’s own marijuana-like transmitters, are involved in  …


Project Twenty21 - June Update

Get Project Twenty21 Updates via Email Project Twenty21 June Update The big news this month is that our Chronic Pain paper has been published! Using Project Twenty21 data, it looks at the characteristics of people seeking prescribed cannabinoids for the treatment of chronic pain. Our results demonstrate the complexities of studying chronic pain, and the  …


Characteristics of People Seeking Prescribed Cannabinoids for the Treatment of Chronic Pain: Evidence From Project Twenty 21

Authors Anne Katrin Schlag, Michael Lynskey, Alan Fayaz, Alkyoni Athanasiou-Fragkouli, Brigitta Brandner, Barbara Haja, Elizabeth Iveson and David J. Nutt Published June 14, 2022 Medical Cannabis for Chronic Pain Chronic pain is a pervasive, and potentially disabling condition. In the UK it is estimated to affect between one third and one half of the adult  …


The Post COVID cathinone hydra

Written by Professor Fiona Measham and Dr Michael Pascoe A study published in the journal of Drug Science Policy and Law describes tumultuous changes to the UK MDMA drug market following Brexit and COVID-19 lockdowns. In this first academic publication from The Loop’s ‘back of house’ testing service, nearly half of substances sold as MDMA were  …


Ketamine for Alcohol Use Disorder

Written by Tiago Vasconcelos. A review of the recent paper – ‘Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder’ by Grabski et al., 2021   Alcohol abuse is one of the costliest conditions affecting modern health and a high proportion of people suffering from alcohol use disorder (AUD) are  …


A critical review of drug testing policy in the Philippines

Authors Carissa Paz Dioquino, Carissa Paz Dioquino Published May 16, 2022 Abstract The drug policy in the Philippines is written as the Comprehensive Dangerous Drugs Act of 2002 or Republic Act 9165. Unlike drug policies in other countries, the law includes policies on drug testing. Aside from mandatory drug testing for specific situations, the law  …


Project Twenty21 - May Update

Get Project Twenty21 Updates via Email Project Twenty21 May Update We are well over the 2500 mark now with the number of patients registered with the project. Thank you for everything you do as supporters of Drug Science to help us spread the word about medical cannabis and Project Twenty21. Our research project with the University  …


Farmability and pharmability: Transforming the drug market to a health-and human rights-centred approach from self-cultivation to safe supply of controlled substances

Authors Fabian Pitter Steinmetz, Maja Kohek Published May 3, 2022 Background The supply chains addressing the global demand for major recreational drugs are hardly addressed due to international contracts, particularly the UN Single Convention on Narcotic Drugs. Currently applied regulatory changes have several disadvantages ranging from political tensions to the neglect of ecological aspects. The  …


Psilocybin Therapy for Treatment-Resistant Depression

Topline Results from COMPASS Pathways Phase IIb Trial   By Olivia Gorzynska In November 2021, COMPASS Pathways, a mental health care company, published a press release announcing results from its phase IIb trial on psilocybin therapy for treatment-resistant depression (TRD). Psilocybin is a naturally occurring psychedelic compound found in mushrooms of the Psilocybe genus. “Magic  …


UK Drugs Inquiry: Drug Science Response

In 2019, Drug Science submitted evidence to the Drugs Policy Inquiry by the Health and Social Care Committee. In 2020, we prepared a detailed report in response to the Dame Carol Black Drugs Review. In 2021, we reacted to the government’s 10-year Drug Strategy. Our 2022 response to the UK government’s call for evidence of  …