How to read a paper on the short-term impairing effects of cannabis: A selective and critical review of the literature

Author Michael A White, Nicholas R Burns Published August 15, 2022 Abstract The prosecution of cannabis-presence driving offences (in the absence of any behavioural evidence of impairment) is ultimately based on the assumption that there is a tight causal relationship between positive toxicology for cannabis and impairment. The main purpose of this review is to  …


Comparative harms assessments for cannabis, alcohol, and tobacco: Risk for psychosis, cognitive impairment, and traffic accident

Author Petter Grahl Johnstad Published July 25, 2022 Abstract Researchers have associated cannabis use with risk for psychosis, cognitive impairment, and traffic accident. However, this review shows that the association between moderate cannabis use and psychosis is no stronger, and often considerably weaker, than the corresponding association for moderate tobacco use. The same holds for  …


State naloxone co-prescribing laws show mixed effects on overdose mortality rates

Author MaryKate Duska, Jared M. Rhoads, Elizabeth C. Saunders, Tracy Onega Published July 25, 2022 Objective To examine the relative changes in opioid overdose mortality rates between states that have and have not adopted naloxone co-prescribing laws. Methods We performed a synthetic control analysis. National Vital Statistics data for the years 2012–2018 were analysed, and  …


Eating ourselves to death: How food is a drug and what food abuse costs

Author Matthew Robinson Published July 18, 2022 Abstract The objective of this paper is to examine definitions of the terms “drug,” “drug use, “drug abuse,” and “addiction” to determine if the most commonly consumed foods in America are similar or consistent with drug use, abuse, and addiction. The methodology consists of reviewing published studies in  …


The Misuse of Drugs Regulations 2001: A case study in poor legislative drafting

Author Cathal T Gallagher Published July 11, 2022 Abstract The Misuse of Drugs Regulations 2001 (MDRs) create exemptions to the offences of possession, production, supply, and administration of controlled drugs (CDs), which are necessary to allow healthcare professionals to treat patients without rendering themselves liable to prosecution for various offences under the Misuse of Drugs  …


Cannabinoids and the endocannabinoid system in fibromyalgia: a review of preclinical and clinical research

Authors Stephanie Bourke, Anne Schlag, Saoirse Elizabeth O’Sullivan, David Nutt, David Finn Published May 21, 2022 Fibromyalgia affects millions of people worldwide and has a significant impact on quality of life. Fibromyalgia symptoms include persistent widespread pain, fatigue, stiffness, sleep disturbances and cognitive dysfunction. Endogenous cannabinoids (endocannabinoids), the body’s own marijuana-like transmitters, are involved in  …


Characteristics of People Seeking Prescribed Cannabinoids for the Treatment of Chronic Pain: Evidence From Project Twenty 21

Authors Anne Katrin Schlag, Michael Lynskey, Alan Fayaz, Alkyoni Athanasiou-Fragkouli, Brigitta Brandner, Barbara Haja, Elizabeth Iveson and David J. Nutt Published June 14, 2022 Medical Cannabis for Chronic Pain Chronic pain is a pervasive, and potentially disabling condition. In the UK it is estimated to affect between one third and one half of the adult  …


The Post COVID cathinone hydra

Written by Professor Fiona Measham and Dr Michael Pascoe A study published in the journal of Drug Science Policy and Law describes tumultuous changes to the UK MDMA drug market following Brexit and COVID-19 lockdowns. In this first academic publication from The Loop’s ‘back of house’ testing service, nearly half of substances sold as MDMA were  …


A critical review of drug testing policy in the Philippines

Authors Carissa Paz Dioquino, Carissa Paz Dioquino Published May 16, 2022 Abstract The drug policy in the Philippines is written as the Comprehensive Dangerous Drugs Act of 2002 or Republic Act 9165. Unlike drug policies in other countries, the law includes policies on drug testing. Aside from mandatory drug testing for specific situations, the law  …


Farmability and pharmability: Transforming the drug market to a health-and human rights-centred approach from self-cultivation to safe supply of controlled substances

Authors Fabian Pitter Steinmetz, Maja Kohek Published May 3, 2022 Background The supply chains addressing the global demand for major recreational drugs are hardly addressed due to international contracts, particularly the UN Single Convention on Narcotic Drugs. Currently applied regulatory changes have several disadvantages ranging from political tensions to the neglect of ecological aspects. The  …


Can psilocybin be safely administered under medical supervision? A systematic review of adverse event reporting in clinical trials

Authors Jeremy Roscoe, Olivia Lozy Published March 16, 2022 Psilocybin is a naturally occurring psychoactive chemical produced by various species of mushroom, mainly in the psilocybe genus. Human consumption of psilocybin, primarily for its psychoactive properties, dates back thousands of years (Tylš et al., 2013). It was first isolated in 1958 by Albert Hoffmann, who was later  …


Are psychedelics dangerous? - What the research says

Authors Anne K Schlag, Jacob Aday, Iram Salam, Jo C Neill, David J Nutt Published February 3, 2022 Psychedelic medicines are a rapidly developing area of clinical research and public health policy. Despite an increasing body of studies highlighting their efficacy to treat a broad range of medical conditions, psychedelic drugs remain a controversial issue  …


Why doctors have a moral imperative to prescribe and support medical cannabis—an essay by David Nutt

Authors David J Nutt Published January 26, 2022 “Medical cannabis has been legal to prescribe since 2018—yet just a handful of prescriptions have been made in three years. The reasons: stigma, fear, and an entrenched resistance in the medical profession that is harming patients” Prof David Nutt – Founder of Drug Science The field of  …


Project Twenty21 - January Update

Get Project Twenty21 Updates via Email We recently announced a change to the pricing model of Project Twenty21. We understand that the news was unwelcome for some patients, especially for those who are prescribed higher dosages or on significantly lower incomes. We take people’s concerns seriously, and recognise that patients would benefit from having more  …


Project Twenty21 in 2022: A Message for Patients

Update What you have helped us achieve so far Our medical cannabis registry, Project Twenty21, was originally designed to run until the end of 2021 (hence the name). As you will know from your own life during the pandemic, the last two years have been full of challenges and obstacles. Project Twenty21 has navigated the  …


Project Twenty21 - December Update

Get Project Twenty21 Updates via Email To mark the end of the year that is our namesake, we’re proud to announce that we’ve reached 2000 patients contributing their data to Project Twenty21. In a recent article for Cannabis Health, our Head of Development, David Horn, reflects on the last two years and our somewhat ambitious goal  …


Leading doctors and scientists call for UK paediatricians to recognise the value of medical cannabis for childhood epilepsy

The British Paediatric Neurology Association (BPNA) recently produced new guidance on the prescription of cannabis medicines for children with epilepsy. However, the Medical Cannabis Clinicians Society (UKMCCS) and Drug Science fundamentally disagree with this guidance. Expert clinicians from both organisations have produced a critique to provide commentary, evidence and further crucial information to guide paediatricians to  …


Professional Perspectives on Treatment for Substance Use Disorders with Mental Health Problems

Authors Ben Houghton, Alexis Bailey, Christos Kouimtsidis, Theodora Duka, Caitlin Notley Published November 25, 2021 Background Opioid-related deaths are at record levels in the UK and contribute to over half of all drug-related deaths. The prevalence of psychiatric disorders within people who uses substances is known to be considerably higher than the general population, yet  …


Is LSD Safe - Latest Research Findings

Is LSD Safe? LSD, technically named lysergic acid diethylamide and also known as acid, is one of the most widely used psychedelic drugs. As it changes both your cognition and your perception, it’s natural to assume this comes with an element of risk and yet LSD is widely regarded to be very safe. But is  …


Project Twenty21 - November Update

Get Project Twenty21 Updates via Email It’s certainly been an eventful past month for Project Twenty21! Drug Science and its supporters celebrated its achievements to date at the House of Lords in mid-October, which included a moving speech from our patient advocate, Lucy Stafford, detailing her journey with medical cannabis.  As Medical Cannabis Awareness Week 2021 (MCAW)  …


Schedule 1 Barriers to Research in the UK: An In-depth Qualitative Analysis

Authors Annie Howard, Joanna C Neill, Anne Katrin Schlag, Charlotte Lennox Published October 25, 2021 Prior to the 1970s, psychedelics such as LSD were used and researched extensively. However, with the introduction of the UN convention Misuse of Drugs Regulations in 2001, all drugs were placed into one of five categories or ‘schedules’ based on  …


The Cocaine Vape - A concept of a harm reduction device for current users of smokable cocaine forms

Authors Fabian P Steinmetz, Heino Stöver Published October 16, 2021 Although there are great regional differences, smokable forms of cocaine (crack, free-base, paco, etc.) are a drug complex associated with often harmful and problematic drug use patterns. While strategies based on drug prohibition did not eradicate the consumption of smokable cocaine forms, prohibition itself led  …


Project Twenty21 - October Update

Get Project Twenty21 Updates via Email   We’re pleased to finally be able to announce that Attention Deficit Hyperactivity Disorder (ADHD) in adults has now been added to the list of indications covered by the study. This means that we will be able to start collecting data on how medical cannabis affects adults diagnosed with ADHD  …