#41 - MDMA and Couples Counselling

This week’s episode features “The Mithoefers” – Annie and Michael Mithoefer – the pioneers of MDMA-assisted psychotherapy.

Michael Mithoefer, MD is a Clinical Investigator and acting Medical Director of MAPS Public Benefit Corporation. Together with his wife Annie, they completed the first phase 2 clinical trial of MDMA-assisted psychotherapy for PTSD in 2009 and a subsequent study of MDMA-assisted psychotherapy for PTSD in military veterans, firefighters and police officers. They are now supervising therapists in the ongoing MAPS Phase 3 trials of MDMA-assisted Psychotheapy for PTSD, leading trainings in MDMA- assisted psychotherapy for therapists interested in working on clinical trials, and providing FDA-approved MDMA sessions for research therapists.

Tune in to this episode to find out about their pioneer work with MDMA and their most recent research!


Who are Michael and Annie Mithoefer? 

Michael Mithoefer is a Clinical Assistant Professor of Psychiatry at the Medical University of South Carolina, is a Grof certified Holotropic Breathwork Practitioner, has been a Certified Internal Family Systems Therapist and has been board certified in Psychiatry, Emergency Medicine and Internal Medicine.

Annie Mithoefer is a registered nurse as well as a Grof-certified Holotropic Breathwork Practitioner, is trained in Hakomi Therapy, and has 25 years of experience working with trauma patients, with an emphasis on experiential approaches to therapy.


MDMA-assisted psychotherapy



Stanislav Grof




Francine Shapiro


Rick Doblin




CAPS-5 – Clinician Administered PTSD Scale

Exposure therapy

Cognitive-behavioral conjoint therapy

Candice Monson


Relax beliefs under psychedelics (REBUS)


EMA – European Medicines Agency



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