Ibogaine
Learn more about ibogaine, the alkaloid gaining rapidly in notoriety.
Overview
Common Nicknames
Eboka/eboga, bitter grass, leaf of God
Drug Class
Psychedelic
Drug Form
Root bark, powder, salt
Route of Administration
Oral
What is the science of Ibogaine?
Ibogaine produces its effects in the body by binding to various receptors in the brain. Firstly, it binds to 5-HT2A serotonin receptors, activating them and modulating the release of neurotransmitters such as GABA, glutamate and dopamine. These serotonin receptors have some control of cognition, memory, appetite, and mood, for example.
Secondly, it binds to k-opioid receptors in the brain, activating them and therefore mediating consciousness, motor control, mood and perception of pain.
Ibogaine is also known to have neuroprotective effects on dopamine and motor neurons, and stimulates the growth of new dopaminergic neurons, which is thought to support the mitigation of cravings for other substances, such as opioids. Dopamine is the main neurotransmitter associated with reward and pleasure and is released when one experiences something that is rewarding. When these dopaminergic neurons are diminished, less dopamine is released from other usually rewarding activities, potentially increasing the cravings for addictive drugs. Evidence for the drug’s effectiveness in this way has been exemplified by the reduction of cocaine and morphine self-administration in animals.
What are the risks?
Taking ibogaine may cause users to experience some unpleasant side effects. These include:
Irregular heartbeats (arrhythmias)
Low blood pressure
Seizures
Gastrointestinal issues
Ibogaine should be taken in a safe and comfortable environment with trusted people present. This will help to alleviate any stress or discomfort which may be experienced and ensure that support is available if needed. Starting with a low dose can also help to reduce the risk of side effects and unpleasant experiences.
How might the drug make you feel?
The effects of ibogaine differ from those of classical hallucinogens such as DMT, LSD, mescaline, and psilocybin.
Low doses of ibogaine can have stimulating effects. At higher doses, often referred to as a “flood dose”, it acts as a oneirogen, producing waking dreamlike states.
Effects of the experience include:
closed eye visualisations
retrieval of repressed memories
profound self-reflection
ataxia
nausea
restlessness
loss of appetite
The effects begin around 1-3 hours post ingestion and can last for 12-36 hours.
Towards the end of the experience, most users experience what is called a “grey day”. As the effects of the ibogaine begin to wear off, the user may experience negative thoughts and feelings and feel guilty, irritable, and upset. The ibogaine experience is long and emotionally taxing, leading to an often uncomfortable recovery period.
Anecdotal reports state that the negative thinking patterns experienced during this “grey day” (which can last for longer than just one day) are those which the user is later liberated from.
Is Ibogaine addictive, and what are the long-term effects?
There is currently no evidence that ibogaine is an addictive substance. Due to the intensity of the ibogaine experience, it is very unlikely that users would like to repeat it regularly.
Harm Reduction and Drug-Drug Interactions
It is vital not to take ibogaine alongside any other drugs. Doing so greatly increases the risks and can lead to fatalities.
Ibogaine reduces physical tolerance to opioids and alcohol. Therefore, extra care should be taken with regards to dosage if a user decides to consume these substances after taking ibogaine.
Ibogaine should be taken in a safe and controlled environment, with a trusted person present.
Ibogaine should not be taken alongside other drugs.
Mixing drugs increases the risks of all substances involved and can be very dangerous.
After undergoing an ibogaine experience, users should abstain from taking any other drugs for at least 90 days. This is to decrease the chances of any dangerous interaction between ibogaine and other substances in the body. Complete detoxification of the body from any drugs (including alcohol) is also recommended before undergoing the experience to minimise risks of harmful interactions in the body.
Medical Uses
Ibogaine is not widely available for medical treatment. However, various clinics have been set up in the US and in Europe which use ibogaine in the treatment of substance abuse. Most notably, ibogaine can be used to help those addicted to certain opioids by treating withdrawal symptoms and reducing or even eliminating cravings and the desire to take the drug again.
A more scientific investigation must be conducted into the use of ibogaine to treat certain mental health disorders. However, anecdotal reports state that taking ibogaine has improved their mental health. The experience can allow people to regain and reflect on memories and process trauma that they have experienced.
Myths and Misconceptions
Ibogaine will make you feel better instantly
Ibogaine will not make users feel instantly cured. The “grey day” after the experience is uncomfortable and can be extremely difficult. However, after this time period has ended, the positive effects of the experience will begin to be felt and can be taken forward into life. Work to ensure that the positive effects continue must be done by the person who has undertaken the ibogaine experience.
Ibogaine is a ‘cure all’
Whilst ibogaine can be very useful in treating the withdrawal symptoms of many opioids, it cannot do so for all of them.
There is also very little scientific evidence to support the use of ibogaine for treating mental health disorders despite anecdotal reports.
Sustainability Concerns
Tabernanthe iboga, the primary source of ibogaine, is critically threatened. This primarily impacts those living in Gabon who rely on the plant for medicine and spirituality.
All exports of iboga are currently banned in Gabon, and projects have been started attempting to regenerate the population of Tabernanthe iboga.
Iboga is protected under the United Nations Nagoya Protocol on Access and Benefit Sharing.
These sustainability concerns have encouraged the move towards using the voacanga tree for the extraction of ibogaine more frequently.