Australia approved the use of psilocybin for treatment-resistant depression in 2023, becoming the first nation to formally integrate the drug into clinical practice. New Zealand, by contrast, kept psilocybin as a Class A controlled drug and confined it almost entirely to research until mid-2025, when it opened a single, tightly bounded route to clinical prescribing without changing the drug’s legal status.

Psychiatric medicine is undergoing a seismic shift as Compass pathways announce successful results from its Phase 3 trial (COMP006).